The XRCC4 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to XRCC4. This antibody recognizes Human, Mouse, and Rat antigen. The XRCC4 Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants